https://sheel031.wixsite.com/cvetanoviclab
The Cvetanovic lab aims to understand how interactions between different brain cells and brain regions influence the pathogenesis of neurodegenerative diseases, focusing on the inherited neurodegenerative disease Spinocerebellar ataxia type 1(SCA1). SCA1 is caused by the expansion of CAG repeat (encoding for glutamine) in the coding region of Ataxin-1 gene and is characterized by severe neurodegeneration in cerebellum.
In particular the Cvetanovic lab studies the involvement of astrocytes and microglia in disease pathogenesis, and role of cerebellar dysfunction in cognitive and mood deficits. The ultimate goal is to increase knowledge of the cellular, molecular and network pathways that underlie pathology of neurodegenerative disorders and open new avenues for therapeutic approaches. The Cvetanovic lab uses mouse genetics, cell and molecular biology techniques, mouse behavior, confocal microscopy and flow cytometry.
