https://med.umn.edu/bio/department-of-radiology/pierre-gilles-henry
The Henry lab focuses on using Magnetic Resonance Spectroscopy (MRS) to understand brain function at the biochemical and cellular level, and to identify new biomarkers of brain disorders. To understand how neurons and astrocytes cooperate metabolically to support neurotransmission, the lab performs tracer studies using 13C-labeled substrates and 13C MRS. The lab also works to develop new metabolic models to analyze 13C MRS data, particularly two-compartment neuronal-glial models to measure the "glutamate-glutamine cycle", to explore the potential of hyperpolarized 13C for the study of brain metabolism and for the detection of tumors in brain and other tissues, and to develop new methodologies for 1H MRS and 1H MRSI at very high-field for the measurement of metabolite concentrations ("neurochemical profile") with improved spatial and temporal resolution.
